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. Author manuscript; available in PMC: 2019 Jul 1.
Published in final edited form as: Neurobiol Dis. 2018 Apr 5;115:115–126. doi: 10.1016/j.nbd.2018.03.014

Figure 7.

Figure 7

P188 suppresses A4VSOD1 membrane toxicity. (A) SB-EP recordings of highly purified A4VSOD1 consistently exhibit “toxic channel” activity (12/12 trials), while the addition of 10 μM P188 reduces this channel activity by ~80% (2/11 trials). Channel activity for hemolysin (HL) was observed in 100% of trials (9/9), and reduced to 50% (3/6) in the presence of P188. (B) By ~10 min post-addition of A4VSOD1, 100% of bilayers under test exhibit “toxic channel” activity (12/12), while only 9% of this activity (1/11) was observed in the presence of P188.