Table 3. Inferred Phosphosite Occupancy on Intact Peptides Derived from Prohormones.
Summary of inferred phosphosite occupancy intensity ratios Log2(+AP/−AP) calculated for the intact forms of known endogenous peptides overlapping at least one verified phosphosite (bold, highlighted). Inferred phosphosite occupancy is calculated from non-phosphorylated peptides. Additional modifications are indicated: oxidized methionine (m), pyroglutamate (q), carbamidomethylation (c), C-term amidation (a), and N-term acetylation (Ac−).
| Name | Sequence | Gene | Log2(+AP/−AP) | p-val |
|---|---|---|---|---|
| Enkelytin |
|
PENK | 10.36* | 0.018 |
| C-flanking pep. of NPY |
|
NPY | 9.26* | 0.015 |
| Enkelytin |
|
PENK | 8.22* | 0.048 |
| Enkelytin |
|
PENK | 8.18* | 0.001 |
| Enkelytin |
|
PENK | 8.05 | 0.140 |
| PENK(233–254) |
|
PENK | 7.81* | 0.042 |
| PENK(233–254) |
|
PENK | 7.73* | 0.037 |
| C-flanking pep. of NPY |
|
NPY | 7.35* | 0.010 |
| O62827(153–188) |
|
ADM | 6.75* | 0.008 |
| Manserin |
|
SCG2 | 6.67* | 0.010 |
| C-terminal peptide |
|
SCG5 | 5.99* | 0.022 |
| Neuropeptide Y |
|
NPY | 5.17* | 0.004 |
| GE-25 |
|
CHGA | 4.61 | 0.130 |
| VIF |
|
CHGA | 2.79* | 0.035 |
| P011211(192–203) |
|
PENK | 1.18 | 0.034 |
| PENK(140–179) |
|
PENK | 1.04 | 0.019 |
| Adrenomedullin-11–26 |
|
ADM | 0.17 | 0.392 |
| Secretolytin (NTE) |
|
CHGB | 0.07 | 0.873 |
| SCG5 Peptide 1 |
|
SCG5 | −0.07 | 0.798 |
| Little LEN |
|
PCSK1N | −0.10 | 0.044 |
| Secretolytin |
|
CHGB | −0.15 | 0.047 |
| P01211(192–203) |
|
PENK | −0.17 | 0.006 |
| Secretolytin |
|
CHGB | −0.30 | 0.031 |
| O62827(45–92) |
|
ADM | −0.34 | 0.010 |
*
Log2(+AP/−AP) > 2.0, p-value < 0.05