Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 May 9;8:7416. doi: 10.1038/s41598-018-25813-x

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Effect of herb 10 before and after β-glucuronidase treatment. 10-Gu: herb 10 after β-glucuronidase treatment. (A) Effect of herb 10 before and after β-glucuronidase treatment on the inflammatory cytokine or glucocorticoid signaling pathway and COX2, iNOS enzyme activity, TNF-α: TNF-α-NFκB luciferase reporter; IL-6: IL-6-STAT3 luciferase reporter; INF-γ: INFγ-GAS luciferase reporter; Dexa: Dexamethasone-GRE luciferase reporter; COX2: COX2 enzyme activity; iNOS: iNOS enzyme activity. +,++: inhibition; −: no impact at concentration ≤750 µg/ml in the inflammatory cytokine or glucocorticoid signaling pathway and at concentration ≤4 mg/ml in COX2, iNOS enzyme activity assay. (B) Effect of herb 10 before and after β-glucuronidase treatment on IL-6 induced mRNA expression of COX2, BCL6, JUNB and IL23. Each bar represents a mean of three different experiments (triplicate samples of each). Compare with +IL-6 group, *p < 0.05; **p < 0.01. (C) Effect of herb 10 before and after β-glucuronidase treatment on INFγ induced mRNA expression of IRF1, IRF9, TAP1, PSMB8 and IFI35. Each bar represents a mean of three different experiments (triplicate samples of each). Compare with +INFγ group, *p < 0.05; **p < 0.01.