Fig. 6.

Comparison of conventional X-ray patterns to merged XFEL patterns. Diffraction patterns from amyloid fibers composed of a Aβ(1–42)¹⁰, b IAPP(1–37)¹⁰, c Aβ(11–25)¹⁰, and d Het-s(218-289)⁵⁸ are shown. The equator and the most prominent layer lines are marked on the right side. The white and black arrow mark the meridional reflection at about 4.8 Å and the equatorial reflection at about ~10 Å characteristic for stacked β-sheets and present in (a–d), respectively. Note, that all amyloid fibrils are non-crystalline except for (c), which is crystalline. Merged XFEL diffraction patterns of bombesin (e) and β-endorphin fibrils (f) extending to 2.4 Å resolution are shown for qualitative comparison. a–c are reprinted from publication¹⁰, Copyright (2010), with permission from Elsevier. d is reprinted from publication⁵⁸ (https://pubs.acs.org/doi/abs/10.1021%2Fbi5002807). Further permissions related to the material excerpted should be directed to the ACS