Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 May 9;8:7389. doi: 10.1038/s41598-018-25764-3

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Shigella sonnei UK cross section in context. The midpoint-rooted maximum likelihood phylogenetic tree shows isolates from this study in the context of five global lineages of S. sonnei. Lineage III has further relevant sublineages indicated at the internal nodes and MSM-associated sublineages are highlighted in grey. Isolates from patients recently returned from endemic regions are indicated by circles overlying the tree tips which are coloured according to the inlaid key. Reference isolates from previously described WGSA subtypes (lineages/sublineages) are indicated in the leftmost adjacent track, and tree branches for references isolates are also coloured according to the inlaid key. AMR features are shown in subsequent tracks. The second leftmost track shows the presence of QRDR mutations and two isolates containing ‘Other’ quinolone resistance determinants (including an isolate with a single QRDR mutation and a qepA gene, and an isolate containing a qnrB19 gene). Subsequent gray scale tracks indicate the presence of antimicrobial resistance genes (ARGs, labelled above) associated with known Shigella MGEs. Specifically (from left to right), the Tn7/Int2, SpA, MSM-associated sublineage 3 plasmid, pKSR100, SRL-MDRE (Table 1).