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. 2018 May 9;8:7345. doi: 10.1038/s41598-018-25595-2

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The graphic abstract of the present study. The dispersing of M-type ferrite particles and mesoporous calcium silicate microspheres within chitosan films consist MCSC scaffolds. The MCSC scaffolds exhibit excellent property in drug delivery and simultaneously improve the efficacy of photothermal therapy under the irradiation of NIR laser. Additionally, the MCSC scaffolds also enhance new bone regeneration effectively by promoting osteogenic differentiation. NIR, near infrared.