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. 2018 May 9;8:7345. doi: 10.1038/s41598-018-25595-2

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The MCSC scaffolds exhibit robust anti-tumor effects in vivo. (A) IR thermal images and (B) temperature curve of MNNG xenograft mice exposed to NIR laser irradiation (red) or not (black). (C) Representative images for tumor volumes at day 12. (D) Relative tumor volume changes. (E) Lentivirus containing EGFP were successfully transfected in MNNG as indicated by fluorescence. (F) Representative images for the whole-body fluorescence imaging of tumors and (G) statistical analysis for intensity and area at day 0 and day 12. (H) Representative histology images of tumor tissues, M represents implanted scaffolds material. (I) Statistical analysis of tumor cell necrosis rate. *P < 0.05. IR, infrared.