Table 3.
RAL plasmatic concentrations [RAL]plasma and [RAL-glu]plasma/[RAL]plasma ratio depending on UGT1A1 allelic status.
| [RAL]plasma (ng/ml)* | p-value | MR | p-value | |||
|---|---|---|---|---|---|---|
|
UGT1A1*1/*1 n = 42 |
88.5 (41.0–236) | 0.03** | 0.03*** | 5.8 (3–10) | 0.006** | 0.005*** |
|
UGT1A1*28 carrier n = 48 |
168 (85.8–318) | 2.9 (1.6–5.3) | ||||
|
UGT1A1*36 carrier n = 6 |
92.5 (36.4–316) | 3.2 (1.7–5.9) | ||||
*Concentrations are expressed as median with interquartile range (IQR).
**Kruskal-Wallis test.
***Steel–Dwass post-hoc test.
MR:metabolic ratio ([RAL-glu]plasma/[RAL]plasma).