Table 1.
Inclusion criteria for case and control definition for overall cancer risk and mortality MR study
| UKB field ID | Description | Case/control criteria |
|---|---|---|
| 134 | (Number of self-reported cancers) | If there is at least one question with a value >0, then it is excluded from the control set |
| 2453 | (Cancer diagnosed by doctor Medical conditions) | |
| 20001 | (Cancer code, self-reported) | If there is at least one question with a value which is not 'NA', then it is excluded from the control set |
| 20007 | (Interpolated age of participant when cancer first diagnosed Medical conditions) as above | If there is at least one question with a value which is not 'NA', then it is excluded from the control set |
| 40001 | (Underlying (primary) cause of death: ICD10—Death register) | If its ICD10 code starts with 'C' or 'D' then exclude from the control set. If the ICD10 code starts with 'C' but is not 'C44' (i.e., not BCC/SCC cases), then it is classified as a case |
| 40006 | (Type of cancer: ICD10—Cancer register) | If its ICD10 code starts with 'C' or 'D' then exclude from the control set. If the ICD10 code starts with 'C' but is not 'C44' (i.e., not BCC/SCC cases), then it is classified as a case |
| 40007 | (Age at death—Death register) | If there is at least one question with a value which is not 'NA', then it is excluded from the control set |
| 40008 | (Age at cancer diagnosis—Cancer register) | If there is at least one question with a value which is not 'NA', then it is excluded from the control set |
| 40011 | (Histology of cancer tumour—Cancer register) | If there is at least one question with a value which is not 'NA', then it is excluded from the control set |
| 40012 | (Behaviour of cancer tumour—Cancer register) | If there is at least one question with a value which is not 'NA', then it is excluded from the control set |
| 40013 | (Type of cancer: ICD9—Cancer register) | If there is at least one question with a value which is not 'NA', then it is excluded from the control set |
| 84 | (Cancer year/age first occurred—Medical conditions) | If there is at least one question with a value which is not 'NA', then it is excluded from the control set |
| 40009 | (Reported occurrences of cancer—Cancer register) | If there is at least one question with a value >0, then it is excluded from the control set |
| 40006 | (Type of cancer: ICD10—Cancer register) | If its ICD10 code starts with 'C' or 'D' then exclude from the control set. If the ICD10 code starts with 'C' but is not 'C44' (i.e., not BCC/SCC cases), then it is classified as a case |
| 41202 | (Diagnoses—main ICD10—Summary Information (diagnoses)) | |
| 41204 | (Diagnoses—secondary ICD10—Summary Information (diagnoses)) | |
| Summary of procedure: Control | Individuals did not report any instance of cancer diagnosis—whether through self-report or clinical diagnosis | |
| Summary of procedure: Cases | Individuals reported instances of cancer diagnosis validated through ICD10 codes starting with 'C'. However, individuals with C44 were excluded |
Caption: Similar criteria were used for the cancer mortality study, mainly we additionally included field ID 40001 and 40002 to validate that cause of death for participants in the study were cancers