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. 2018 Jan 22;25(5):966–982. doi: 10.1038/s41418-017-0036-9

Fig. 2. Myocardial infarction induced increases in YAP1/TAZ expression and nuclear translocation in WT neonatal hearts, but not in TLR3 deficient neonatal mice.

Fig. 2

1 day old (P1) neonatal wild type (WT) and TLR3 deficient (TLR3-/-) mice were subjected to (MI). a, b Cytosolic and nuclear proteins were isolated from the neonatal hearts for analysis of YAP and TAZ levels in the cytosol a and the nuclei b. c, d The TLR3 ligand, Poly I:C increased the level of YAP1 in the cytosol c and promotes YAP1 nuclear translocation d in WT neonatal cardiomyocytes, but not in TLR3-/- neonatal cardiomyocytes. e, f Inhibition of glycolysis by 2-DG prevents Poly I:C-induced increases in YAP1 expression in cytosol e and nuclear translocation f. n = 3–6/group. *p < 0.05 compared with indicated groups