Fig. 9. Illustration of TLR3-mediated YAP1 activation and miR-152 expression in cardiomyocyte proliferation.

Activation of TLR3 increased glycolysis, resulting in inactivation of LATS and AMPK by reduced phosphorylation. Inactivated LATS and AMPK lead to activation of YAP1 which, as a co-transcriptional factor regulated miR-152 expression. miR-152 suppressed p27kip1 and DNMT1 expression, promoting cell proliferation