. 2018 Mar 21;118(9):1243–1247. doi: 10.1038/s41416-018-0046-5

Table 2.

MAP kinase pathway activating mutations in conjunctival melanoma

Gene		Mutation type	Tumours harbouring mutation
			N	%
BRAF		All mutations	16	25
		V600E	16	25
RAS		All mutations	12	19
	NRAS	Q61R	5	8
		Q61K	2	3
		Q61H	1	2
		Q61L	1	2
		G13D	1	2
		G12N, G12C	1	2
	KRAS	G12A	1	2
NF1		All mutations	21	33
		T60del	1	2
		R262C	1	2
		C42Y, G2397R, S2587L	1	2
		S2751N, L552P, G2392E	1	2
		D176E	2	3
		L847P, P866S, V1762I	1	2
		C1899Y	1	2
		M1180I, S52F; T60I	1	2
		A2715V; A2208T	1	2
		G2397R, R2517fs	1	2
		I1824fs	1	2
		L1892^a	1	2
		N1451L	1	2
		Q1815^a	1	2
		Q756fs	1	2
		R1362^a	1	2
		R440^a, Q2239^a; S1497F; V1393A	1	2
		S168L	1	2
		S1786^a, L1102^a; Q1815fs	1	2
		Y1678fs	1	2
Wild type			14	22
Total			63

MAP mitogen-activated protein, fs frameshift mutations

^aNonsense mutations