Table 2.

Diagnostic performance of miRNAs for colorectal cancer detection

	Median log10‐expression		P a	Adjusted P b	Apparent AUC	.632+ AUC	.632+ sensitivity
	Controls	CRC cases					At 80% specificity	At 90% specificity
miR.21	−8.0	−6.8	<0.001	<0.001	0.84	0.84	78	62
miR.25	−8.9	−8.5	<0.001	<0.001	0.65	0.63	46	31
miR.18a	−10.2	−9.8	0.003	0.036	0.59	0.56	29	12
miR.22	−9.7	−10.2	0.004	0.046	0.59	0.55	26	12
miR.15b	−8.7	−8.4	0.005	0.054	0.58	0.57	28	20
miR.142.5p	−10.1	−9.7	0.015	0.176	0.57	0.54	22	13
miR.29c	−9.7	−9.6	0.116	1.392	0.53	0.5	22	13
miR.19a	−9.3	−9.1	0.595	7.144	0.49	0.45	14	6
miR.16	−8.4	−8.4	0.541	6.486	0.49	0.44	14	7
miR.192	−10.3	−10.4	0.555	6.658	0.49	0.46	19	9
miR.26a	−7.8	−8.0	0.806	9.674	0.48	0.43	17	8
miR.150	−9.0	−9.0	0.752	9.029	0.46	0.43	15	7

^aWilcoxon signed‐rank test for difference in miRNA expression distribution between CRC cases and controls.

^bThe P‐value was adjusted for multiple testing by the Bonferroni method by multiplying the nominal P‐value with 12 (the number of miRNAs analyzed).