Table 2.
Median log10‐expression | P a | Adjusted P b | Apparent AUC | .632+ AUC | .632+ sensitivity | |||
---|---|---|---|---|---|---|---|---|
Controls | CRC cases | At 80% specificity | At 90% specificity | |||||
miR.21 | −8.0 | −6.8 | <0.001 | <0.001 | 0.84 | 0.84 | 78 | 62 |
miR.25 | −8.9 | −8.5 | <0.001 | <0.001 | 0.65 | 0.63 | 46 | 31 |
miR.18a | −10.2 | −9.8 | 0.003 | 0.036 | 0.59 | 0.56 | 29 | 12 |
miR.22 | −9.7 | −10.2 | 0.004 | 0.046 | 0.59 | 0.55 | 26 | 12 |
miR.15b | −8.7 | −8.4 | 0.005 | 0.054 | 0.58 | 0.57 | 28 | 20 |
miR.142.5p | −10.1 | −9.7 | 0.015 | 0.176 | 0.57 | 0.54 | 22 | 13 |
miR.29c | −9.7 | −9.6 | 0.116 | 1.392 | 0.53 | 0.5 | 22 | 13 |
miR.19a | −9.3 | −9.1 | 0.595 | 7.144 | 0.49 | 0.45 | 14 | 6 |
miR.16 | −8.4 | −8.4 | 0.541 | 6.486 | 0.49 | 0.44 | 14 | 7 |
miR.192 | −10.3 | −10.4 | 0.555 | 6.658 | 0.49 | 0.46 | 19 | 9 |
miR.26a | −7.8 | −8.0 | 0.806 | 9.674 | 0.48 | 0.43 | 17 | 8 |
miR.150 | −9.0 | −9.0 | 0.752 | 9.029 | 0.46 | 0.43 | 15 | 7 |
Wilcoxon signed‐rank test for difference in miRNA expression distribution between CRC cases and controls.
The P‐value was adjusted for multiple testing by the Bonferroni method by multiplying the nominal P‐value with 12 (the number of miRNAs analyzed).