Table 3.
Study | ORR (predeleted) | Study | ORR (postdeleted) | ||||
---|---|---|---|---|---|---|---|
Median | 95% CI | Median | 95% CI | ||||
Total | 20% | 16–24% | Total | 18% | 15–20% | ||
2012 | Topalian et al. | 18% | 10–27% | 2012 | Topalian et al. | 18% | 10–27% |
2013 | Rizvi et al. | 32% | 18–46% | 2013 | Rizvi et al. | 32% | 18–46% |
2014 | Antonia et al. | 16% | 6–26% | 2014 | Antonia et al. | 16% | 6–26% |
2014 | Antonia et al. | 22% | 10–34% | 2014 | Antonia et al. | 22% | 10–34% |
2014 | Ramalingam et al. | 12% | 5–18% | 2014 | Ramalingam et al. | 12% | 5–18% |
2014 | Rizvi et al. | 9% | 0–19% | 2015 | Bauer et a | 14% | 9–18% |
2015 | Bauer et a | 14% | 9–18% | 2015 | Borghaei et al. | 19% | 15–24% |
2015 | Borghaei et al. | 19% | 15–24% | 2015 | Brahmer et al. | 20% | 13–27% |
2015 | Brahmer et al. | 20% | 13–27% | 2015 | Gettinger et al. | 17% | 11–24% |
2015 | Gettinger et al. | 17% | 11–24% | 2015 | Nishio et al. | 22% | 14–29% |
2015 | Nishio et al. | 22% | 14–29% | 2015 | Rizvi et al. | 14% | 8–21% |
2015 | Rizvi et al. | 14% | 8–21% | 2016 | Crino et al. | 18% | 14–22% |
2016 | Bidoli et al. | 4% | 1–7% | 2016 | Gettinger et al. | 23% | 12–35% |
2016 | Crino et al. | 18% | 14–22% | Overall (I 2 = 20.6%, P = 0.235); Egger's test (P = 0.098) | |||
2016 | Gettinger et al. | 23% | 12–35% | ||||
2016 | Rizvi et al. | 43% | 30–56% | ||||
2017 | Hellmann et al. | 43% | 32–54% | ||||
2016 | Nishio et al. | 25% | 15–35% | ||||
2017 | Carbone et al. | 26% | 21–31% | ||||
Overall (I 2 = 87.3%, P < 0.001); Egger's test (P = 0.002) |