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. 2018 Mar 23;7(5):1642–1659. doi: 10.1002/cam4.1387

Table 3.

Pooled objective response rate (ORR) and modified objective response rate (ORR) in non‐small‐cell lung cancer (NSCLC) patients for included studies

Study ORR (predeleted) Study ORR (postdeleted)
Median 95% CI Median 95% CI
Total 20% 16–24% Total 18% 15–20%
2012 Topalian et al. 18% 10–27% 2012 Topalian et al. 18% 10–27%
2013 Rizvi et al. 32% 18–46% 2013 Rizvi et al. 32% 18–46%
2014 Antonia et al. 16% 6–26% 2014 Antonia et al. 16% 6–26%
2014 Antonia et al. 22% 10–34% 2014 Antonia et al. 22% 10–34%
2014 Ramalingam et al. 12% 5–18% 2014 Ramalingam et al. 12% 5–18%
2014 Rizvi et al. 9% 0–19% 2015 Bauer et a 14% 9–18%
2015 Bauer et a 14% 9–18% 2015 Borghaei et al. 19% 15–24%
2015 Borghaei et al. 19% 15–24% 2015 Brahmer et al. 20% 13–27%
2015 Brahmer et al. 20% 13–27% 2015 Gettinger et al. 17% 11–24%
2015 Gettinger et al. 17% 11–24% 2015 Nishio et al. 22% 14–29%
2015 Nishio et al. 22% 14–29% 2015 Rizvi et al. 14% 8–21%
2015 Rizvi et al. 14% 8–21% 2016 Crino et al. 18% 14–22%
2016 Bidoli et al. 4% 1–7% 2016 Gettinger et al. 23% 12–35%
2016 Crino et al. 18% 14–22% Overall (I 2  = 20.6%, = 0.235); Egger's test (= 0.098)
2016 Gettinger et al. 23% 12–35%
2016 Rizvi et al. 43% 30–56%
2017 Hellmann et al. 43% 32–54%
2016 Nishio et al. 25% 15–35%
2017 Carbone et al. 26% 21–31%
Overall (I 2  = 87.3%, < 0.001); Egger's test (= 0.002)