Table 2.
The relationships between NOTCH1 mutations and clinical features
| Variables | Total (n) | NOTCH1 mutation (n) | NOTCH1 wild type (n) | P value |
|---|---|---|---|---|
| Gender | 317 | 29 | 288 | |
| Male | 216 | 23 | 193 | 0.176 |
| Female | 101 | 6 | 95 | |
| Age | 317 | 29 | 288 | |
| >60 | 169 | 16 | 153 | 0.833 |
| ≤60 | 148 | 13 | 135 | |
| Rai | 302 | 28 | 274 | |
| 0 | 27 | 0 | 27 | 0.086 |
| 1–2 | 150 | 12 | 138 | |
| 3–4 | 125 | 16 | 109 | |
| Binet | 302 | 28 | 274 | |
| A | 98 | 2 | 96 | 0.010 |
| B | 92 | 11 | 81 | |
| C | 112 | 15 | 97 | |
| CD38 | 288 | 27 | 261 | |
| ≥30% | 78 | 13 | 65 | 0.010 |
| <30% | 210 | 14 | 196 | |
| ZAP‐70 | 256 | 23 | 233 | |
| ≥20% | 118 | 13 | 105 | 0.293 |
| <20% | 138 | 10 | 128 | |
| IGHV status | 295 | 29 | 266 | |
| IGHV M | 165 | 6 | 159 | <0.001 |
| IGHV UM | 130 | 23 | 107 |