Table 2.
Metaanalysis of the association of the 24 SNPs with response to MTX assessed as ΔDAS28 at 6 months in the four populations of RA patients.
| Locus | SNP | MA | Fixed effects | Heterogeneity | Random effects | |||
|---|---|---|---|---|---|---|---|---|
| β (SE) | P | I2 | P | β (SE) | P | |||
| Candidate gene | ||||||||
| ABCB1 | rs1045642 | A | 0.02 (0.04) | 0.6 | 28 | 0.2 | 0.02 (0.05) | 0.7 |
| ABCC1 | rs35592 | C | 0.03 (0.05) | 0.6 | 71 | 0.02 | −0.04 (0.10) | 0.7 |
| AMPD1 | rs17602729 | A | −0.11 (0.07) | 0.10 | 61 | 0.05 | −0.17 (0.12) | 0.15 |
| ATIC | rs4673990 | G | 0.08 (0.04) | 0.07 | 6 | 0.4 | 0.08 (0.05) | 0.09 |
| rs12995526 | A | 0.04 (0.04) | 0.4 | 36 | 0.2 | 0.02 (0.06) | 0.7 | |
| rs16853834 | T | 0.04 (0.06) | 0.6 | 11 | 0.3 | 0.04 (0.07) | 0.6 | |
| rs2372536 | G | 0.07 (0.05) | 0.1 | 17 | 0.3 | 0.07 (0.06) | 0.2 | |
| ITPA | rs2295553 | C | 0.09 (0.04) | 0.040 | 0 | 0.6 | 0.09 (0.04) | 0.040 |
| rs1127354 | A | 0.07 (0.09) | 0.4 | 19 | 0.3 | 0.06 (0.10) | 0.5 | |
| MTRR | rs1801394 | A | −0.14 (0.04) | 0.0016 | 24 | 0.3 | −0.15 (0.05) | 0.0056 |
| MTHFD1 | rs2236225 | A | −0.06 (0.05) | 0.2 | 0 | 0.8 | −0.06 (0.05) | 0.2 |
| SLC46A1 | rs2239907 | T | −0.01 (0.04) | 0.7 | 0 | 0.6 | −0.01 (0.04) | 0.7 |
| TYMS | rs699517 | T | −0.03 (0.05) | 0.5 | 57 | 0.07 | 0.00 (0.08) | 1.0 |
| GWAS hit | ||||||||
| ARL14/PPM1L | rs7624766 | G | −0.03 (0.05) | 0.5 | 0 | 0.5 | −0.03 (0.05) | 0.5 |
| BMP2 | rs2650972 | T | −0.04 (0.04) | 0.4 | 0 | 0.8 | −0.04 (0.04) | 0.4 |
| DHFR | rs5836788 | del | −0.01 (0.05) | 0.8 | 0 | 0.5 | −0.01 (0.05) | 0.8 |
| 10p15.1 | rs1901633 | G | 0.05 (0.05) | 0.3 | 0 | 0.7 | 0.05 (0.05) | 0.3 |
| 14q13.1 | rs4982133 | A | −0.06 (0.05) | 0.3 | 0 | 1.0 | −0.06 (0.05) | 0.3 |
| 15q26.2 | rs1703794 | C | −0.01 (0.05) | 0.8 | 0 | 0.4 | −0.01 (0.05) | 0.8 |
| 20q13 | rs6064463 | C | −0.06 (0.05) | 0.2 | 11 | 0.3 | −0.06 (0.05) | 0.3 |
| MTRR | rs162040 | C | −0.07 (0.06) | 0.3 | 60 | 0.06 | −0.07 (0.11) | 0.5 |
| PTPRM | rs6506569 | C | 0.02 (0.05) | 0.6 | 0 | 0.8 | 0.02 (0.05) | 0.6 |
| TYMS | rs2244500 | G | 0.02 (0.05) | 0.6 | 64 | 0.04 | 0.07 (0.09) | 0.4 |
| rs2847153 | A | 0.02 (0.06) | 0.7 | 0 | 0.5 | 0.02 (0.06) | 0.7 | |
Summary regression coefficients (β) and their standard errors (SE) obtained with fixed effects and random effects metaanalysis are presented together with the inconsistency (I2) and P value of the Cochran Q test for heterogeneity. Multivariate linear regression in each population included sex, age, baseline DAS28, previous use of DMARD and concomitant treatment with corticosteroids.