Table 3.
Metaanalysis of the association of the 24 SNPs with response to MTX according to the EULAR criteria at 6 months in the four populations of RA patients.
| Locus | SNP | MA | Fixed effects | Heterogeneity | Random effects | |||
|---|---|---|---|---|---|---|---|---|
| OR (95% CI) | P | I2 | P | OR (95% CI) | P | |||
| Candidate gene | ||||||||
| ABCB1 | rs1045642 | A | 0.95 (0.8–1.2) | 0.6 | 22 | 0.3 | 0.97 (0.7–1.2) | 0.8 |
| ABCC1 | rs35592 | C | 1.19 (0.9–1.5) | 0.2 | 61 | 0.05 | 1.24 (0.8–1.9) | 0.3 |
| AMPD1 | rs17602729 | A | 1.08 (0.8–1.5) | 0.6 | 42 | 0.2 | 1.14 (0.7–1.8) | 0.6 |
| ATIC | rs4673990 | G | 0.73 (0.6–0.9) | 0.009 | 0 | 0.5 | 0.73 (0.6–0.9) | 0.009 |
| rs12995526 | A | 0.85 (0.7–1.1) | 0.1 | 52 | 0.10 | 0.86 (0.6–1.2) | 0.4 | |
| rs16853834 | T | 0.91 (0.7–1.3) | 0.6 | 0 | 0.5 | 0.91 (0.7–1.3) | 0.6 | |
| rs2372536 | G | 0.72 (0.6–0.9) | 0.009 | 8 | 0.4 | 0.72 (0.6–0.9) | 0.014 | |
| ITPA | rs2295553 | C | 0.81 (0.6–1.02) | 0.1 | 0 | 1.0 | 0.81 (0.6–1.02) | 0.1 |
| rs1127354 | A | 0.74 (0.5–1.1) | 0.2 | 0 | 0.6 | 0.74 (0.5–1.1) | 0.2 | |
| MTRR | rs1801394 | A | 1.39 (1.1–1.8) | 0.004 | 0 | 0.6 | 1.39 (1.1–1.8) | 0.004 |
| MTHFD1 | rs2236225 | A | 1.03 (0.8–1.3) | 0.8 | 0 | 0.5 | 1.03 (0.8–1.3) | 0.8 |
| SLC46A1 | rs2239907 | T | 0.96 (0.8–1.2) | 0.7 | 0 | 0.8 | 0.96 (0.8–1.2) | 0.7 |
| TYMS | rs699517 | T | 1.03 (0.8–1.3) | 0.8 | 0 | 0.6 | 1.03 (0.8–1.3) | 0.8 |
| GWAS hit | ||||||||
| ARL14/PPM1L | rs7624766 | G | 1.13 (0.9–1.4) | 0.3 | 47 | 0.13 | 1.15 (0.8–1.6) | 0.4 |
| BMP2 | rs2650972 | T | 1.28 (1.02–1.6) | 0.035 | 0 | 0.8 | 1.28 (1.02–1.6) | 0.035 |
| DHFR | rs5836788 | del | 1.00 (0.8–1.3) | 1.0 | 17 | 0.3 | 1.00 (0.8–1.3) | 1.0 |
| 10p15.1 | rs1901633 | G | 0.88 (0.7–1.1) | 0.3 | 0 | 0.9 | 0.88 (0.7–1.1) | 0.3 |
| 14q13.1 | rs4982133 | A | 1.19 (0.9–1.6) | 0.2 | 0 | 0.7 | 1.19 (0.9–1.6) | 0.2 |
| 15q26.2 | rs1703794 | C | 1.12 (0.9–1.5) | 0.4 | 5 | 0.4 | 1.12 (0.8–1.5) | 0.4 |
| 20q13 | rs6064463 | C | 1.17 (0.9–1.5) | 0.2 | 0 | 0.5 | 1.17 (0.9–1.5) | 0.2 |
| MTRR | rs162040 | C | 1.35 (0.98–1.9) | 0.1 | 0 | 1.0 | 1.35 (0.98–1.9) | 0.1 |
| PTPRM | rs6506569 | C | 0.89 (0.7–1.1) | 0.3 | 0 | 0.5 | 0.89 (0.7–1.1) | 0.3 |
| TYMS | rs2244500 | G | 0.89 (0.7–1.1) | 0.4 | 0 | 0.9 | 0.89 (0.7–1.1) | 0.4 |
| rs2847153 | A | 1.02 (0.8–1.4) | 0.9 | 0 | 0.7 | 1.02 (0.8–1.4) | 0.9 | |
Summary odds ratios (OR) and their confidence intervals (95% CI) obtained with fixed effects and random effects metaanalysis are presented together with the inconsistency (I2) and p value of the Cochran Q test for heterogeneity. Multivariate logistic regression in each population included sex, age, baseline DAS28, previous use of DMARD and concomitant treatment with corticosteroids.