Table 2.
Replicated associations (P ≤ 10−5) from the cross‐disease meta‐analysis for endometriosis and endometrial cancer
| Chr | BP | Lead SNP | Flanking gene/genesa | Effect allele | Noneffect allele | GWAS meta‐analysis | Replication meta‐analysis | P het | ||
|---|---|---|---|---|---|---|---|---|---|---|
| OR (95% CI) | P‐value | OR (95% CI) | P‐value | |||||||
| 9 | 10260263 | rs2475335 | PTPRD | T | C | 1.15 (1.09–1.21) | 2.1 × 10−6 | 1.11 (1.07–1.15) | 4.9 × 10−8 | 0.46 |
| 3 | 73981773 | rs9865110 | PDZRN3‐CNTN3 | C | A | 1.11 (1.06–1.16) | 9.4 × 10−5 | 1.10 (1.06–1.14) | 2.6 × 10−6 | 0.002 |
| 17 | 46262171 | rs2278868 | SKAP1 | C | T | 0.87 (0.82–0.93) | 4.7 × 10−7 | 0.92 (0.88–0.96) | 5.5 × 10−6 | 0.05 |
| 12 | 89299016 | rs12303900 | KITLG‐DUSP6 | G | T | 1.30 (1.17–1.43) | 9.7 × 10−5 | 1.28 (1.17–1.38) | 5.7 × 10−6 | 0.08 |
| 6 | 50715407 | rs9349553 | TFAP2D | T | C | 1.14 (1.08–1.19) | 4.5 × 10−6 | 1.09 (1.05–1.13) | 9.0 × 10−6 | 0.02 |
| 4 | 38765720 | rs10008492 | KLF3‐TLR10 | T | C | 1.14 (1.08–1.19) | 2.3 × 10−6 | 1.08 (1.05–1.12) | 1.3 × 10−5 | 0.07 |
| 13 | 77164473 | rs9530566 | LMO7‐KCTD12 | C | A | 1.12 (1.07–1.17) | 3.3 × 10−5 | 1.08 (1.05–1.12) | 1.7 × 10−5 | 0.054 |
| 12 | 4253697 | rs10459129 | PARP11‐CCND2 | A | G | 0.89 (0.83–0.95) | 6.8 × 10−5 | 0.90 (0.86–0.95) | 2.1 × 10−5 | 0.44 |
| 19 | 31364717 | rs2198894 | ZNF536‐TSHZ3 | T | C | 1.11 (1.06–1.16) | 8.4 × 10−5 | 1.09 (1.05–1.13) | 2.4 × 10−5 | 0.49 |
| 9 | 32907608 | rs7042500 | THEM215‐APTX | A | G | 0.86 (0.79–0.93) | 1.2 × 10−5 | 0.90 (0.86–0.95) | 4.0 × 10−5 | 0.07 |
| 17 | 63665556 | rs17693745 | CEP112 | T | C | 1.12 (1.07–1.18) | 2.3 × 10−5 | 1.08 (1.04–1.12) | 5.3 × 10−5 | 0.24 |
| 1 | 22473410 | rs7515106 | WNT4‐ZBTB40 | C | T | 1.15 (1.08–1.21) | 1.2 × 10−5 | 1.09 (1.04–1.14) | 7.0 × 10−5 | 0.0036 |
| 6 | 57186294 | rs1755833 | PRIM2 | A | G | 0.89 (0.84–0.95) | 3.9 × 10−5 | 0.93 (0.89–0.97) | 7.9 × 10−5 | 0.007 |
a
Only one gene is listed for SNPs located within genes (introns or exons).