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. 2018 Mar 25;7(5):1896–1907. doi: 10.1002/cam4.1406

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© 2018 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Protein–protein interaction (PPI) map of the 26 potential druggable targets. (A) Potentially druggable targets were used to construct a PPI network using the online tool STRING. Blue nodes represent proteins involved in cell cycle. Red and green nodes represent proteins associated with DNA damage and angiogenesis, respectively. The nodes indicate proteins coded by the identified druggable targets and edges indicate the number of interactions. The number of average interactions per node is represented by the node degree. The clustering coefficient indicates the average node density of the map. (B) List of hub proteins according the number of interactions (edges) in the druggable PPI network.