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. 2018 May 3;8:143. doi: 10.3389/fonc.2018.00143

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Copyright © 2018 Hamilton, McCampbell and Palena.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Brachyury drives resistance to TNF-related apoptosis-inducing ligand (TRAIL) in cells expressing a wild-type p53 gene. (A) Western blot analysis of brachyury, vimentin, E-cadherin, and p21 in H460 clones generated via the CRISPR/Cas9 system. (B,C) Western blot analysis of brachyury expression in HCT116 and H1229 cells, respectively, stably transfected with either a control or brachyury-encoding (pBr) plasmid. (D) The impact of brachyury expression on the sensitivity of HCT116 (left panel) and H1229 (right panel) to lysis by a range of TRAIL doses.