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. 2018 May 3;9:480. doi: 10.3389/fphys.2018.00480

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Copyright © 2018 Braun, Zollbrecht, Dietze, Schubert, Golz, Summer, Persson, Carlström, Ludwig and Patzak.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Illustration of applied chemicals (bold) to affect the NO/sGC/cGMP signaling pathway; SNP, sodium nitroprusside; NO, nitric oxide; NOS, nitric oxide synthase; L-NAME, Nω-nitro-L-arginine methylester hydrochloride; L-Arg, L-arginine; O₂^-, superoxide; GTP, guanosine triphosphate; sGC, soluble guanylyl cyclase; ODQ, 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one; GMP, guanosine monophosphate; cGMP, cyclic guanosine monophosphate; 8-Br-cGMP, 8-bromoguanosine 3’,5’-cyclic monophosphate sodium salt; PKG, cGMP-dependent protein kinase; DT-2, DT-2 trifluoroacetate salt; PDE, phosphodiesterase; tempol, 4-hydroxy-TEMPO. (^∗) – activation, (–) – inhibition.