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. 2018 May 3;9:480. doi: 10.3389/fphys.2018.00480

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Copyright © 2018 Braun, Zollbrecht, Dietze, Schubert, Golz, Summer, Persson, Carlström, Ludwig and Patzak.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of H/R on sGC-dependent relaxation in isolated rat renal interlobar arteries (ILAs) precontracted with PE. (A) Inhibition of PKG kinase by DT-2 could not reverse H/R effect on ILA relaxation [EC_50: 2.14^∗10^-8 mol/l (control) vs. 4.88^∗10^-8 mol/l (H/R); P < 0.05]. Mean ± SEM. (^∗) indicates significant differences. (B) The sGC inhibitor ODQ abolished the H/R effect on ILA relaxation and aligned control and H/R dose–response relationships [8.90^∗10^-7 mol/l (control) vs. 1.70^∗10^-6 mol/l (H/R); EC₅₀ not significant, ANOVA not significant].