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. 2018 May 3;9:904. doi: 10.3389/fimmu.2018.00904

Figure 2.

Figure 2

miR-155 deficiency ameliorates colitis by affecting inflammatory signaling in mucosal immune cells. The bone marrow chimeras were reconstructed and 7–8 weeks later treated with 3% dextran sulfate sodium as in Figure 1A. (A) Schematic of bone marrow chimera reconstructions. (B–D) Body weight (B) and DAI (C) were monitored daily, and colon length of each bone marrow chimeras was examined at day 11(D). (E) The cytokine concentrations in the supernatants of 24 h cultured colon explants were assessed by ELISA and were normalized by total colon tissue weight in whole-colon culture. *P < 0.05, **P < 0.01, WT → miR-155−/− mice vs miR-155−/− → miR-155−/− mice. ns, not significant, miR-155−/− → WT mice vs miR-155−/− → miR-155−/−. Student’s t-test in (A–D); n = 11–14 per group. Data are representative of two independent experiments (mean and SD). BM, bone marrow; WT, wild-type.