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. 2018 May 3;9:438. doi: 10.3389/fphar.2018.00438

FIGURE 1.

FIGURE 1

Atorvastatin markedly improved the stability of vulnerable atherosclerotic plaques in ApoE-/- mice. (A) Representative images of the en face aorta Oil Red O staining plaque burden (red) from vehicle-treated and atorvastatin-treated mice. (B) Gross morphology and quantification of plaque areas in entire aortas, n = 3. (C) Anatomical view of the aortic arch from different groups under a dissecting microscope; black arrowheads represent atherosclerotic lesions in the aortic arch. (D) Vulnerable atherosclerotic plaques in the left common carotid artery were collected and sectioned. These sections were stained with hematoxylin and eosin (HE), Masson stain, and Oil Red O, scale bar = 200 μm. (E) Representative immunohistochemical staining of CD68 for macrophages, scale bars = 200 μm. Data are presented as mean ± SEM. ∗P < 0.05 vs. the vehicle group, ∗∗P < 0.01 vs. the vehicle group. Vehicle, mice were given saline solution alone. Ator 10, atorvastatin at 10 mg/kg/day. Ator 20, atorvastatin at 20 mg/kg/day.