FIGURE 4.

Heatmaps of coverage distribution over the 11 assembled sequences by the metagenomic reads from the training, validation, and testing samples. (A) Heatmap of the reads coverage of the 11 assembled sequences across the training and validation samples (83 healthy individuals and 98 LC patients). (B) Heatmap of the reads coverage of the 11 assembled sequences across the testing samples (30 healthy individuals and 25 LC patients). The coverage is the read-alignment depth in each nucleotide normalized by the number of million reads. To avoid the effect of large span, we use the logarithm of (coverage+1) as the numerical value of the heatmaps. The horizontal axis is composed of each nucleotide of the 11 sequences, and the vertical axis is composed of healthy individuals and patients. The upper part of each heatmap is the healthy group, and the lower part is the patient group.