Figure 8.

Effect of carboplatin or hyperoxia treatment on the apoptosis of lung in benzo[a]pyrene (B[a]P)-induced lung cancer mouse model. A representative transferase-mediated dUTP nick end-labeling (TUNEL) staining of lung sections showed the apoptotic status (apoptotic nuclei, shown as arrows). (A) No TUNEL-positive cells were detected in B[a]P + CON group. TUNEL-positive cells were present in lung cancer tissue sections in (B) B[a]P + CAR or (C) B[a]P + H group. (D) In the B[a]P + CAR + H group, significantly increased number of TUNEL-positive cells were observed (×200). CON, control group; CAR, carboplatin group; H, hyperoxia group.