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Proposed mouse model. Following exposure, Mtb resides inside the lung macrophages and replicate by using host iron to cause infection. Fth−/− mice tries to reduce the availability of iron in the lung cells by upregulating FPN, an iron exporter. FtH is essential for maintaining mitochondrial function through oxidative phosphorylation (OXPHOS) and demonstrated an essential role for FtH in maintenance of central intermediary metabolism.
