Table I.
Histopathological factors assessed in study population.
| Histopathological factors | Subjects with PNI (n=18) | Subjects without PNI (n=192) | P-valuea |
|---|---|---|---|
| Age, yearsb | 47.06 (±7.78) | 44.22 (±8.56) | 0.908 |
| FIGO stage, n (%) | 0.286 | ||
| Ia2 | 0 | 3 (1.56) | |
| Ib1 | 5 (27.78) | 80 (41.67) | |
| Ib2 | 10 (55.56) | 64 (33.33) | |
| IIa1 | 0 | 17 (8.85) | |
| IIa2 | 3 (16.67) | 28 (14.58) | |
| Pathology, n (%) | 0.352 | ||
| SCC | 16 (88.89) | 157 (81.77) | |
| Adeno/adenosquamous carcinoma | 2 (11.11) | 35 (18.23) | |
| Histological grade, n (%) | 0.371 | ||
| Well differentiated | 2 (11.11) | 30 (15.62) | |
| Moderate differentiation | 6 (33.33) | 88 (45.83) | |
| Poor differentiation | 10 (55.56) | 74 (38.54) | |
| Tumor size | 0.045 | ||
| ≤4 cm | 5 (27.78) | 99 (51.56) | |
| >4 cm | 13 (72.22) | 93 (48.44) | |
| Depth of invasion | <0.001 | ||
| <2/3 | 2 (11.11) | 111 (57.81) | |
| ≥2/3 | 16 (88.89) | 81 (42.19) | |
| Parametrial invasion | <0.001 | ||
| Present | 8 | 2 | |
| Absent | 10 | 190 | |
| LVSI | 0.005 | ||
| Present | 7 | 22 | |
| Absent | 11 | 170 | |
| Lymph nodes metastases | 0.001 | ||
| Positive | 10 | 34 | |
| Negative | 8 | 158 | |
| Positive vaginal margin | 0.518 | ||
| Positive | 1 | 7 | |
| Negative | 17 | 185 |
a
Comparison between patients with and without PNI.
b
Data are presented as the mean ± standard deviation. PNI, perineural invasion; SCC, squamous cell carcinoma; LVSI, lymphovascular space invasion; FIGO, International Federation of Gynecology and Obstetrics.