Table 3.
Summary of mean (standard deviation) pharmacokinetic parameters in healthy male subjects administered three different doses of THC:CBD oromucosal spray (Stott et al., 2013)
| Parameter | Δ9‐tetrahydrocannabinol (THC) number of sprays (dose) | ||
|---|---|---|---|
| Two sprays (5.4 mg) | Four sprays (10.8 mg) | Eight sprays (21.6 mg) | |
| Single‐dose study | |||
| Cmax (μg/L) | 1.5 (0.5) | 4.0 (2.3) | 5.4 (2.4) |
| Tmax (h) | 1.0 (0.8–1.5) | 1.5 (0.8–2.0) | 1.0 (0.8–1.5) |
| AUC0‐inf (μg/L h) | 3.5 (1.8) | 12.5 (7.3) | 24.7 (20.7) |
| Multiple‐dose study | |||
| Cmax (μg/L) | 1.4 (0.6) | 2.7 (1.5) | 6.9 (2.1) |
| Cmin (μg/L) | NC | 0.1 (0.03) | 0.4 (0.2) |
| Tmax (h) | 1.6 (range 1.0–4.0) | 1.5 (range (0.8–2.5) | 3.3 (1.0–6.0) |
| AUC0‐τ (μg/L h) | 4.1 (1.6) | 9.9 (3.7) | 39.9 (4.7) |
AUC0‐inf, area under the plasma concentration versus time curve from time 0 to infinity; AUC0‐τ, area under the plasma concentration versus time curve over the final dosing interval (0‐24 h); Cmax, maximum plasma concentration; Cmin, minimum plasma concentration; NC, not calculated; Tmax, time to Cmax.