Table 4.
Pharmacokinetic parameters for THC:CBD oromucosal spray (Sativex), for vaporized THC extract and smoked cannabis (Huestis et al., 1992; Summary of Product Characteristics, Sativex Oromucosal Spray, 2017)
| THC pharmacokinetic parameters | |||
|---|---|---|---|
| Cmax ng/ml | Tmax min | AUC (0‐t) ng/ml min | |
| Sativex (providing 21.6 mg THC) | 5.4 | 60 | 1,362 |
| Inhaled vaporized THC extract (providing 8 mg THC) | 118.6 | 17 | 5,987.9 |
| Smoked cannabisa (providing 33.8 mg THC) | 162.2 | 9 | No data |
AUC0‐t, area under the plasma concentration versus time curve (0‐designated time); Cmax, maximum plasma concentration; Tmax, time to Cmax.
a
Huestis et al., Journal of Analytical Toxicology 1992; 16:276–82.