Table 1.

MR metrics in patients with WD and the healthy controls

	SN		TH		CA		GP		PU		Cerebellum
	Left	Right	Left	Right	Left	Right	Left	Right	Left	Right	Left	Right
FA
WD	0.47 ± 0.20a	0.42 ± 0.15a	0.37 ± 0.15	0.34 ± 0.12a	0.24 ± 0.11	0.28 ± 0.08	0.36 ± 0.14a	0.37 ± 0.11a	0.26 ± 0.15	0.26 ± 0.13	0.35 ± 0.13b	0.30 ± 0.12
Controls	0.63 ± 0.09	0.60 ± 0.09	0.42 ± 0.10	0.42 ± 0.07	0.27 ± 0.10	0.28 ± 0.08	0.50 ± 0.04	0.55 ± 0.03	0.33 ± 0.06	0.35 ± 0.03	0.27 ± 0.13	0.26 ± 0.13
λ1
WD	1.04 ± 0.34	1.01 ± 0.17	0.91 ± 0.25b	1.00 ± 0.33	1.08 ± 0.18	0.99 ± 0.17	0.82 ± 0.21a , b	1.17 ± 0.36a	0.81 ± 0.51a , b	0.95 ± 0.47a	0.79 ± 0.30b	0.81 ± 0.26
Controls	1.23 ± 0.13	1.17 ± 0.08	1.02 ± 0.11	0.92 ± 0.14	1.05 ± 0.07	1.10 ± 0.15	1.18 ± 0.26	1.40 ± 0.09	1.47 ± 0.07	1.38 ± 0.02	0.87 ± 0.13	0.94 ± 0.13
λ2
WD	0.78 ± 0.22	0.73 ± 0.22	0.73 ± 0.14	0.78 ± 0.19	0.82 ± 0.24	0.84 ± 0.17	0.82 ± 0.16a , b	0.98 ± 0.34a	1.14 ± 0.44a	1.04 ± 0.2a	0.62 ± 0.23	0.71 ± 0.27
Controls	0.77 ± 0.14	0.74 ± 0.08	0.74 ± 0.09	0.76 ± 0.13	0.76 ± 0.21	0.88 ± 0.14	0.64 ± 0.12	0.74 ± 0.05	0.72 ± 0.05	0.81 ± 0.05	0.54 ± 0.13	0.65 ± 0.13
λ3
WD	0.51 ± 0.23	0.46 ± 0.22	0.48 ± 0.19	0.53 ± 0.16	0.64 ± 0.17	0.63 ± 0.15	0.56 ± 0.18b	0.65 ± 0.26	0.87 ± 0.35a	0.84 ± 0.22a	0.46 ± 0.25	0.54 ± 0.26
Controls	0.41 ± 0.07	0.46 ± 0.09	0.40 ± 0.11	0.41 ± 0.09	0.65 ± 0.13	0.54 ± 0.13	0.56 ± 0.10	0.57 ± 0.05	0.50 ± 0.07	0.49 ± 0.04	0.48 ± 0.13	0.57 ± 0.13
CP
WD	1,817 ± 47a , b	1,837 ± 52a	2,054 ± 21a , b	2,075 ± 24a	2,024 ± 36a	2,013 ± 41a	1,996 ± 37	1,989 ± 42	2,013 ± 52a	2,009 ± 39a	2,093 ± 27a	2,080 ± 46a
Controls	2,019 ± 77	2,015 ± 63	2,132 ± 32	2,129 ± 41	2,085 ± 45	2,088 ± 62	2,013 ± 69	2,019 ± 52	2,063 ± 23	2,071 ± 51	2,155 ± 19	2,169 ± 21
ALFF
WD			6.81 ± 3.34b	5.51 ± 3.76a	5.05 ± 3.67a	5.25 ± 3.51a	6.70 ± 0.78	6.76 ± 1.08	6.35 ± 0.82a	6.55 ± 1.06a
Controls			7.56 ± 0.50	7.85 ± 0.54	8.22 ± 0.62	8.23 ± 0.65	7.01 ± 0.79	6.98 ± 0.77	7.30 ± 0.81	7.40 ± 0.72
REHO
WD			6.08 ± 3.39a , b	7.27 ± 3.02	6.16 ± 3.34a	6.19 ± 3.41	7.41 ± 0.98	7.23 ± 1.90	7.48 ± 1.86	7.68 ± 1.83
Controls			8.17 ± 0.88	7.87 ± 2.20	8.41 ± 0.73	7.31 ± 2.83	7.77 ± 0.65	7.65 ± 2.17	7.44 ± 2.04	6.72 ± 3.24

ALFF, amplitude of low‐frequency fluctuation; PU, putamen; GP, globus pallidus; CA, head of the caudate nucleus; TH, thalamus; SN, substantia nigra; REHO, regional homogeneity; WD, Wilson's disease.

Results reported as mean±SEM.

^a p ≤ .05 compared with healthy controls.

^b p ≤ .05 compared with the right side.