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Stimulation of protein synthesis by mTORC1. In quiescent cells, 4E-BP is hypophosphorylated and tightly associated with eIF4E, thus preventing translation initiation. When activated, mTORC1 phosphorylates 4E-BP leading to its dissociation from eIF4E and assembly of the eIF4F complex. 4E-BP repression by mTORC1 stimulates global protein synthesis.
