Table 2.
Evaluation of Chubak breast cancer algorithms for recurrence in the LACE study (n = 1535)*
| Single Chubak algorithms |
MR Yes
Alg Yes |
MR No
Alg Yes |
MR Yes
Alg No |
MR No
Alg No |
Sensitivity | Specificity | PPV | NPV |
|---|---|---|---|---|---|---|---|---|
| Single algorithms | ||||||||
| SBCE | ||||||||
| Algorithm 1 | 266 | 76 | 41 | 1152 | 86.6 | 93.8 | 77.8 | 96.6 |
| Algorithm 2 | 244 | 31 | 63 | 1197 | 79.5 | 97.5 | 88.7 | 95.0 |
| Algorithm 3 | 257 | 344 | 50 | 884 | 83.7 | 72.0 | 42.8 | 94.6 |
| Recurrences | ||||||||
| Algorithm 1 | 223 | 119 | 29 | 1164 | 88.5 | 90.7 | 65.2 | 97.6 |
| Algorithm 2 | 206 | 69 | 46 | 1214 | 81.7 | 94.6 | 74.9 | 96.3 |
| Algorithm 3 | 206 | 395 | 46 | 888 | 81.7 | 69.2 | 34.3 | 95.1 |
| Algorithm 7 | 144 | 58 | 108 | 1225 | 57.1 | 95.5 | 71.3 | 91.9 |
| Algorithm 8 | 201 | 73 | 51 | 1210 | 79.8 | 94.3 | 73.4 | 96.0 |
| Algorithm 9 | 188 | 34 | 64 | 1249 | 74.6 | 97.3 | 84.7 | 95.1 |
| Algorithm 10 | 186 | 288 | 66 | 995 | 73.8 | 77.6 | 39.2 | 93.8 |
* Alg = algorithm; LACE = Life After Cancer Epidemiology study; MR = medical record; NPV = negative predictive value; PPV = positive predictive value; SBCE = second breast cancer event.