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. 2018 Mar 29;39(5):858–865. doi: 10.1038/aps.2018.1

Figure 5.

Figure 5

Neurobehavioural performance after HI is improved with DCPIB treatment. (A) Summary of geotaxis reflex test on Day 1, Day 3, and Day 7 (when mouse pups were P8, P10, and P14, respectively) across animals from all groups: sham (n=5), control HI (n=4), and DCPIB-treated HI (n=4). Animals in the control HI group consistently had a slower reflex, either significant (*P<0.05) or clearly trending towards significance. Note that comparisons were made between groups on each respective day (compared to the sham group). The general trend is that DCPIB-treatment improves geotaxis reflex towards that of sham animals. (B) Summary of cliff avoidance reflex test on Day 1, Day 3, and Day 7 (when mouse pups were P8, P10, and P14, respectively) across animals from all groups: sham (n=5), control HI (n=4), and DCPIB-treated HI (n=4). Animals in the control HI group consistently had a significant slower reflex (*P<0.05). Note that comparisons were made between groups on each respective day (compared to the sham group). The general trend is that DCPIB-treatment improves cliff avoidance reflex towards that of sham animals. (One-way ANOVA with Bonferonni multiple comparison test).