Figure 6.

Schematic of proposed model of mechanism underlying the swelling-induced Cl⁻ current I_Cl,swell in HI brain injury. Following hypoxic and ischemic insult, there is aberrant activity of the swelling-induced Cl⁻ current I_Cl,swell. This can lead to neuronal death and result in brain damage. Ultimately, neurobehavioural performance may be negatively affected. However, this outcome can be reversed with treatment using the specific swelling-induced Cl⁻ current I_Cl,swell antagonist DCPIB. Aberrant swelling-induced Cl⁻ current I_Cl,swell activity is reduced. Consequently, there is less neuronal death and brain damage, which would contribute to improved neurobehavioural performance.