Figure 2.

TRPM2 Structure. TRPM2 is comprised of intracellular amino and carboxy-terminal regions and six transmembrane segments with a re-entry loop that forms a pore between segments 5 and 6. The amino terminus contains the TRPM2 homology domain, which is largely conserved across all TRPM family members. The amino terminus also contains a Ca²⁺-calmodulin (CaM) binding motif that participates in channel activation. The carboxy terminus contains a highly conserved TRP box (TRP), a coiled-coiled region (CCR) that may participate in tetrameric assembly, and the nucleoside diphosphate-linked moiety X-type homology motif (NUDT9-H), which binds adenosine diphosphate ribose (ADPR), the intracellular agonist for TRPM2.