Table 8.

In vitro activity of 3o and 3p against clinical isolates of S. aureus expressed as a minimal inhibitory concentration (MIC) (µg/mL) and a minimal bactericidal concentration (MBC) (µg/mL). OX: oxacillin, AMP: ampicillin, NTF: nitrofurantoin, STR: streptomycin.

Compound	3o		3p		OX		AMP		NTF		STR
Tested Strain	MIC	MBC	MIC	MBC	MIC	MBC	MIC	MBC	MIC	MBC	MIC	MBC
naso-pharynx isolates
S. aureus
C4	32	64	256	256	0.25	0.25	512	512	16	16	8	8
C7	32	64	256	256	0.25	0.25	64	128	16	16	8	16
C8	32	64	256	256	0.25	0.25	512	>512	16	16	8	16
C19	32	64	256	256	0.5	0.25	64	128	32	32	8	8
ulcers/furuncles isolates
D12	32	64	256	256	0.5	0.5	256	256	32	32	8	16
F1	32	64	256	256	0.25	0.25	128	128	32	32	8	8
F7	32	64	256	256	0.25	0.25	4	4	16	16	8	16
F12	32	64	256	256	0.25	0.25	64	128	16	32	8	32
bone isolates
D14	32	64	256	256	0.5	0.5	256	512	32	32	8	16
D15 (MRSA)	32	64	256	512	>512	>512	>512	>512	32	32	256	>512
D17 (MRSA)	32	64	256	512	>512	>512	>512	>512	32	32	256	>512
D20	32	64	256	512	0.5	0.5	128	256	16	32	8	8