Table 1.
No. | Essential Oils Components | AChE Source | IC50 (mM) | Ki (mM) | Reference |
---|---|---|---|---|---|
1 | Anisaldehyde | BxACE-1 from Bursaphelenchus xylophilus | 4.95 | [46] | |
BxACE-2 from Bursaphelenchus xylophilus | 8.53 | [46] | |||
BxACE-3 from Bursaphelenchus xylophilus | >50 | [46] | |||
2 | Camphene | Blatella germanica | N.A. | [47] | |
3 | Camphor | Blatella germanica | N.A. | [47] | |
4 | 3-Carene | BxACE-1 from Bursaphelenchus xylophilus | 0.37 | [46] | |
BxACE-2 from Bursaphelenchus xylophilus | 8.18 | [46] | |||
BxACE-3 from Bursaphelenchus xylophilus | >50 | [46] | |||
5 | Carvacrol | Musca domestica | 0.0012 | [48] | |
Dermacentor variabilis | 0.0018 | [48] | |||
Periplaneta americana | 0.0004 | [48] | |||
Aedes aegypti | 0.0012 | [48] | |||
Drosophila suzukii | N.A. | [49] | |||
Sitophilus oryzae | 0.05 | [50] | |||
6 | Caryophyllene (humulene) | Blatella germanica | N.A. | [47] | |
7 | 1,8-Cineole | Pediculus humanus capitis | 77 | [51] | |
Sitophilus oryzae | 0.084 | [50] | |||
8 | Coniferyl alcohol | BxACE-1 from Bursaphelenchus xylophilus | 1.06 | [46] | |
BxACE-2 from Bursaphelenchus xylophilus | 1.41 | [46] | |||
BxACE-3 from Bursaphelenchus xylophilus | 1.13 | [46] | |||
9 | Cymene | Sitophilus oryzae | 0.05 | [50] | |
Drosophila suzukii | N.A. | [49] | |||
10 | Estragole (Allylanisole) | Blatella germanica | N.A. | [47] | |
11 | Eugenol | Sitophilus oryzae | 0.096 | [50] | |
12 | Isoeugenol | Sitophilus oryzae | 0.11 | [50] | |
13 | Isosafrole | Sitophilus oryzae | 0.71 | [50] | |
14 | Limonene | Sitophilus oryzae | 0.73 | [50] | |
Reticulitermes speratus Kolbe | 0.95 | [41] | |||
15 | Linalool | Sitophilus oryzae | N.A. | [50] | |
16 | Methyleugenol | Sitophilus oryzae | 0.051 | [50] | |
17 | Menthol | Sitophilus oryzae | 0.048 | [50] | |
Drosophila suzukii | N.A. | [49] | |||
18 | Menthone | Sitophilus oryzae | 0.39 | [50] | |
Drosophila suzukii | N.A. | [49] | |||
19 | Nerolidol | BxACE-1 from Bursaphelenchus xylophilus | 9.98 | [46] | |
BxACE-2 from Bursaphelenchus xylophilus | 15.28 | [46] | |||
BxACE-3 from Bursaphelenchus xylophilus | 19.06 | [46] | |||
20 | Nootkatone | Musca domestica | >30 | [48] | |
Dermacentor variabilis | >30 | [48] | |||
Periplaneta americana | >30 | [48] | |||
Aedes aegypti | >30 | [48] | |||
21 | Ocimene | Japanese termite | 0.96 | [52] | |
Blatella germanica | N.A. | [47] | |||
22 | Perilla aldehyde | Drosophila suzukii | 3.06 | [49] | |
23 | Phellandrene | Reticulitermes speratus Kolbe | 4.92 | [41] | |
Blatella germanica | 2.2 | [47] | |||
24 | α-Pinene | Sitophilus oryzae | 0.44 | [50] | |
BxACE-1 from Bursaphelenchus xylophilus | 0.24 | [46] | |||
BxACE-2 from Bursaphelenchus xylophilus | 0.64 | [46] | |||
BxACE-3 from Bursaphelenchus xylophilus | 0.68 | [46] | |||
Reticulitermes speratus Kolbe | 3 | [41] | |||
25 | β-Pinene | BxACE-1 from Bursaphelenchus xylophilus | 3.39 | [46] | |
BxACE-2 from Bursaphelenchus xylophilus | 18.03 | [46] | |||
BxACE-3 from Bursaphelenchus xylophilus | >50 | [46] | |||
Reticulitermes speratus Kolbe | 3.08 | [41] | |||
Sitophilus oryzae | 0.0028 | [50] | |||
26 | α-Terpinene | Sitophilus oryzae | 0.14 | [50] | |
27 | α-Terpineol | Sitophilus oryzae | 3.94 | [50] | |
28 | β-Thujone | Blatella germanica | N.A. | [47] | |
29 | Thymol | Sitophilus oryzae | 0.57 | [50] | |
Drosophila suzukii | 4.26 | [49] |
N.A.—the compound is not active or the inhibition is lower than 50%; IC50—Concentration of component that cause 50% inhibition of enzyme; Ki—inhibitory constant. BxACE-1, BxACE-2 and BxACE-3 are three different acetylcholinesterases found in Bursaphelenchus xylophilus. Values in mg/mL were recalculated by the authors of this paper.