Skip to main content
. 2017 Dec 23;23(1):34. doi: 10.3390/molecules23010034

Table A1.

The effects of the essential oil components on the acetylcholinesterase activity in organisms other than insects.

No. Essential Oil Components AChE Source IC50 (mM) Ki (mM) Reference
1 Anisaldehyde Electric eel N.A. [122]
2 Anisole Human erythrocyte N.A. [123]
3 Anethole Electric eel N.A. [124]
Electric eel [67]
Electric eel 0.88 [125]
Electric eel 8.9 [126]
Bovine erythrocyte 0.2 [127]
Electric eel N.A. [122]
Electric eel N.A. [128]
Electric eel 0.87 [126]
4 Borneol Bovine erythrocyte N.A. [64]
Human erythrocyte N.A. [68]
Bovine erythrocyte N.A. [63]
Electric eel N.A. [122]
Human erythrocyte N.A. [123]
Electric eel N.A. [124]
5 Bornyl acetate Electric eel 21.3 [55]
Human erythrocyte N.A. [68]
Bovine erythrocyte N.A. [63]
6 Camphene Electric eel N.A. [122]
7 Camphor Electric eel 0.05 [67]
Electric eel N.A [124]
Electric eel 11.2 [60]
Human erythrocyte N.A. [68]
Bovine erythrocyte N.A. [63]
Electric eel N.A. [122]
Human erythrocyte N.A. [123]
8 2-Carene Bovine erythrocyte 0.9 [58]
9 3-Carene Human erythrocyte 0.2 [68]
Bovine erythrocyte 0.2 [58]
Electric eel 0.26 [126]
10 Carvacrol Electric eel 0.41 [65]
Electric eel 0.61 [126]
Electric eel 0.21 [122]
Electric eel 0.76 [128]
11 Carvone Electric eel 0.3 [67]
Bovine erythrocyte N.A. [64]
Electric eel N.A. [122]
Electric eel 5.5 [60]
12 Caryophyllene (humulene) Human erythrocyte N.A. [68]
Bovine erythrocyte 0.13 [68]
Electric eel N.A. [124]
Human erythrocyte N.A. [68]
Electric eel N.A. [129]
13 Caryophyllene oxide Human erythrocyte N.A. [68]
Bovine erythrocyte N.A. [63]
14 1,8-Cineole Electric eel 0.025 [55]
Electric eel 0.1 [124]
Electric eel 0.71 [126]
Bovine erythrocyte 0.26 [64]
Electric eel 0.6 [51]
Electric eel 0.84 [122]
Human erythrocyte 0.4 [68]
Electric eel 0.04 0.03 [57]
Bovine erythrocyte 0.29 0.1 [58]
Bovine erythrocyte 0.39 [63]
Human erythrocyte 0.67 [130]
15 Cinnamaldehyde Electric eel N.A. [122]
16 Cinnamyl alcohol Electric eel N.A. [122]
17 Citral Electric eel 7 [55]
Electric eel N.A. [124]
Electric eel N.A. [122]
18 Citronellal Electric eel N.A. [122]
19 Citronellol Electric eel N.A. [122]
20 Copaene Human erythrocyte N.A. [68]
21 Cymene Bovine erythrocyte N.A. [58]
22 Elemol Bovine erythrocyte 0.16 [64]
23 Estragole (Allylanisole) Electric eel 0.15 [67]
Electric eel 12.6 [60]
Electric eel N.A. [124]
Electric eel N.A. [122]
24 Eugenol Electric eel 2.9 [124]
Electric eel N.A. [122]
Human erythrocyte N.A. [123]
25 Fenchone Electric eel 0.4 [67]
Electric eel 7 [60]
26 Geraniol Electric eel 0.1 [67]
Electric eel 15 [60]
Electric eel N.A. [122]
27 Globulol Human erythrocyte N.A. [68]
28 Gossypol Electric eel 1.5 [55]
29 Guaiol Human erythrocyte N.A. [68]
30 Isoeugenol Electric eel N.A. [122]
31 Limonene Electric eel N.A. [124]
Human erythrocyte N.A. [68]
Electric eel 1.61 [125]
Electric eel 4.33 [126]
Electric eel N.A. [122]
Bovine erythrocyte N.A. [64]
32 Linalool Electric eel 0.3 [67]
Electric eel 5.5 [55]
Electric eel N.A. [124]
Electric eel 15.6 [60]
Electric eel N.A. [122]
Human erythrocyte N.A. [68]
Bovine erythrocyte N.A. [63]
Bovine erythrocyte N.A. [64]
33 Linalyl acetate Bovine erythrocyte N.A. [64]
Electric eel N.A. [129]
34 Manool Human erythrocyte N.A. [68]
35 Methylcinnamate Electric eel N.A. [122]
36 Methyleugenol Electric eel N.A. [122]
Electric eel N.A. [124]
37 Menthofuran Bovine erythrocyte N.A. [64]
38 Menthol Bovine erythrocyte N.A. [64]
39 Menthone Bovine erythrocyte N.A. [64]
Electric eel N.A. [122]
40 Methol Human erythrocyte N.A. [123]
41 Methoxycinnamaldehyde Electric eel N.A. [124]
42 Methyl acetate Bovine erythrocyte N.A. [64]
43 Myrcene Electric eel N.A. [122]
44 Myrtenal Electric eel 0.17 [122]
45 Nerol Electric eel N.A. [122]
46 Nerolidol Electric eel N.A. [122]
47 Neryl acetate Human erythrocyte N.A. [68]
48 Phellandrene Electric eel 0.88 [129]
49 Phenylethanol Electric eel N.A. [122]
50 α-Pinene Electric eel 0.16 [124]
Electric eel 10.5 [130]
Human erythrocyte 0.7 [68]
Human erythrocyte 0.63 [131]
Bovine erythrocytes 0.66 [63]
Electric eel N.A. [122]
Bovine erythrocytes 0.4 [58]
51 β-Pinene Electric eel N.A. [124]
Human erythrocyte 1.5 [68]
Bovine erythrocyte 1.5 [63]
Electric eel N.A. [122]
52 Piperitenone oxide Bovine erythrocyte 0.38 [64]
53 Piperitenone Bovine erythrocyte 0.72 [64]
Bovine erythrocyte 0.83 [64]
54 Pulegone Electric eel 0.85 [55]
Bovine erythrocyte 0.89 [64]
55 Sabinene Human erythrocyte N.A. [68]
Electric eel 1.25 [125]
56 Sclareol Human erythrocyte N.A. [68]
57 α-Terpinene Bovine erythrocyte N.A. [58]
58 γ-Terpinene Electric eel 0.2 [67]
Electric eel N.A. [124]
Electric eel 5.8 [60]
Bovine erythrocyte N.A. [58]
59 α-Terpineol Electric eel 8.43 [124]
Human erythrocyte N.A. [68]
60 Terpinen-4-ol Electric eel 20.7 [124]
Electric eel 10.30 4.7 [57]
Bovine erythrocyte N.A. 2 [58]
Electric eel N.A. [129]
Electric eel N.A. [122]
61 Terpinolene Electric eel 1.1 [129]
62 α-Thujone Human erythrocyte N.A. [68]
Electric eel N.A. [122]
63 Thymohydroquinone Electric eel 0.24 [65]
64 Thymol Electric eel 4.9 [65]
Electric eel 1.39 [126]
Electric eel N.A. [122]
65 Thymoquinone Electric eel 0.85 [65]
66 Viridiflorol Bovine erythrocyte 0.11 [64]
67 Verbenone Electric eel 2.66 [122]
Electric eel 0.73 [128]

N.A.—the compound is not active or the inhibition is lower than 50%; IC50—Concentration of component that cause 50% inhibition of enzyme; Ki—inhibitory constant. Values in mg/mL were recalculated by the authors of this paper.