Table 6.
Antibacterial activity of 26 in combination with common antibiotics against MRSA in the biofilm. MBEC, minimum biofilm eradication concentration. FICI, fractional inhibitory concentration index.
| Combinations | MRSA ATCC 33591 |
||||
|---|---|---|---|---|---|
| MBEC (mg/L) | FICI | Outcome | |||
| Alone | Combined | ||||
| 1 | 26 | 16 | 16 | 2 | Independent |
| Vancomycin | >64 | >64 | |||
| 2 | 26 | 8 | 8 | 2 | Independent |
| Gentamycin | >64 | >64 | |||
| 3 | 26 | 8 | 8 | 2 | Independent |
| Ampicillin | >64 | >64 | |||
| 4 | 26 | 16 | 16 | 2 | Independent |
| Ofloxacin | >64 | >64 | |||
| 5 | 26 | 16 | 16 | 2 | Independent |
| Trimethoprim | >64 | >64 | |||
| 6 | 26 | 16 | 16 | 2 | Independent |
| Tetracycline | >64 | >64 | |||
| 7 | 26 | 8 | 8 | 2 | Independent |
| Erythromycin | >64 | >64 | |||
| 8 | 26 | 32 | 32 | 2 | Independent |
| Daptomycin | >64 | >64 | |||
| 9 | 26 | 16 | 16 | 2 | Independent |
| Linezolid | >64 | >64 | |||
| 10 | 26 | 16 | 16 | 2 | Independent |
| Chloramphenicol | >64 | >64 | |||
| 11 | 26 | 8 | 1 | 0.375 | Synergy |
| Rifampicin | 8 | 2 | |||