Table 1.
MiRNAs whose expression changed in human CPT2-deficient primary fibroblasts as compared with control primary human fibroblasts, as deduced from microRNA microarray analysis. Geometric mean of intensities <100 were considered as background and discarded. Changes were considered significant for p < 0.05.
| miRNAs | Fold Change | Increasing Parametric p Value |
|---|---|---|
| miRNAs upregulated in CPT2-deficient fibroblasts: | ||
| 483 | 3.1 | 1.6 × 10−6 |
| 301 | 11.43 | 4.1 × 10−6 |
| 449b | 1.99 | 2.79 × 10−6 |
| 206 | 3.38 | 9.39 × 10−6 |
| 550-1 | 2.83 | 0.000171 |
| 539 | 2.04 | 0.0002213 |
| 661 | 2.79 | 0.0004408 |
| 371 | 2.65 | 0.0005968 |
| 10b | 2.75 | 0.0011091 |
| 9 | 4.4 | 0.0014253 |
| 550-2 | 2.1 | 0.0016581 |
| 651 | 2.87 | 0.0019172 |
| 196a-2 | 2.09 | 0.0019172 |
| miRNAs downregulated in CPT2-deficient fibroblasts: | ||
| let-7d | 0.16 | <1 × 10−7 |
| 211 | 0.14 | 4 × −10−7 |
| let-7a3 | 0.22 | 1.2 × 10−6 |
| 198 | 0.14 | 2.8 × 10−6 |
| 141 | 0.28 | 4.6 × 10−6 |
| 136 | 0.31 | 5.1 × 10−6 |
| 203 | 0.24 | 5.7 × 10−6 |
| 127 | 0.23 | 7.7 × 10−6 |
| 181c | 0.26 | 1.85 × 10−5 |
| 496 | 0.3 | 2.5 × 10−5 |
| 126-5p | 0.14 | 3.64 × 10−5 |
| 144 | 0.097 | 3.8 × 10−5 |
| let-7g | 0.48 | 4.14 × 10−5 |
| 181a2 | 0.44 | 4.42 × 10−5 |
| 618 | 0.48 | 4.47 × 10−5 |
| 41 | 0.15 | 4.5 × 10−5 |
| 299-5p | 0.14 | 4.73 × 10−5 |
| 1 | 0.41 | 4.88 × −10−5 |
| 145 | 0.32 | 4.94 × 10−5 |
| 25 | 0.26 | 6.37 × 10−5 |
| 123 | 0.31 | 6.67 × 10−5 |
| 200b | 0.27 | 8.33 × 10−5 |
| 325 | 0.44 | 8.51 × 10−5 |
| 593 | 0.42 | 9.19 × 10−5 |
| 24-5p/189 | 0.14 | 0.0001524 |
| 125b2 | 0.1 | 0.0002071 |
| 123 | 0.25 | 0.0002196 |
| 154-5p | 0.3 | 0.0002281 |
| 184 | 0.43 | 0.0002499 |
| 199b | 0.47 | 0.0005099 |
| 22 | 0.25 | 0.0006033 |
| 363-3p | 0.37 | 0.0006076 |
| 338 | 0.24 | 0.0007282 |
| 146a | 0.42 | 0.0008154 |
| 212 | 0.28 | 0.0008813 |
| 196a-1 | 0.34 | 0.0008916 |
| 500 | 0.29 | 0.0013401 |
| 563 | 0.47 | 0.0016458 |