Table 2.

RSV (75 μM) treatment impacts miRNA expression in control and in CPT2-deficient fibroblasts, compared with the corresponding DMSO-treated primary fibroblasts, as deduced from microRNA microarray analysis. Geometric mean of intensities <100 were considered as background and discarded. Changes were considered significant when p < 0.05.

Control Fibroblasts						CPT2-Deficient Fibroblasts
Upregulation by RSV			Downregulation by RSV			Upregulation by RSV			Downregulation by RSV
miRNA	Fold Change	Increasing Parametric p Value	miRNA	Fold Change	Increasing Parametric p Value	miRNA	Fold Change	Increasing Parametric p Value	miRNA	Fold Change	Increasing Parametric p Value
321	3.67	0.0003277	35	0.47	0.0011099	219	1.81	0.00028111	101-1/2	0.51	0.000758
594	3.33	0.000695	548a-1	0.28	0.0011964	299-5p	1.94	0.00037058	181d	0.45	0.00021178
550-2	2.65	0.0026216	566	0.49	0.0014556	193a	1.96	0.00074255	16-1	0.48	0.00022522
565	2.87	0.0066109	620	0.49	0.0031365	199a1-5p	1.8	0.035782	21	0.47	0.00023066
611	2.18	0.0100121	92b	0.24	0.003498	548a1	2.3	0.041391	99a*	0.27	0.00041291
483	2.29	0.0118661	378-5p	0.41	0.0070053	337	1.89	0.0488272	20b	0.47	0.00053956
335	2.69	0.0158687	579	0.19	0.020456				let-7d	0.46	0.00071834
550-1	2.35	0.0182839	136	0.46	0.0206073				17-5p	0.43	0.0007255
449b-1	1.99	0.021485	let-7f	0.44	0.0220297				146a	0.27	0.0110431
661	2.45	0.0256413	211	0.24	0.0220881				566	0.5	0.012436
326	3.58	0.0315627	376a-2	0.42	0.024334				376b	0.47	0.012361
196a-1	3.45	0.0369082	193a	0.23	0.0255173				26a	0.46	0.0130816
			29a	0.47	0.0265262				103-1	0.35	0.0166397
			199b	0.44	0.0294717				let-7c	0.28	0.0192349
			141	0.26	0.029536				423	0.14	0.0231317
			204	0.33	0.0295895				23a	0.18	0.0257826
			216	0.3	0.0311748
			let-7a3	0.29	0.0323893
			618	0.44	0.0361713
			198	0.43	0.0375283
			22	0.39	0.0379847
			126-5p	0.26	0.0463448
			23b	0.49	0.0469568
			144	0.26	0.0496528