Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 May 9;37:100. doi: 10.1186/s13046-018-0748-9

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

PMC Copyright notice

Fig. 3 — The expression of ABCB4, CYP2C8, UGT2B4 and UGT2B17 was upregulated by SPIN1 in breast cancer cells. a Candidate SPIN1 targets from microarray were presented as a heat map. b-c The mRNA expression levels of ABCB4, CYP2C8, UGT2B4, and UGT2B17 were decreased after SPIN1 siRNA transfection. Accordingly, overexpression of SPIN1 led to upregulation of ABCB4, CYP2C8, UGT2B4, and UGT2B17 mRNA expression levels. d-e Western blot analysis confirmed that overexpression of SPIN1 upregulated ABCB4, CYP2C8, UGT2B4, and UGT2B17 protein levels, however, SPIN1 downregulation decreased the expression levels of these proteins. f-i Data from PPISURV (ABCB4 and UGT2B4) and GOBO (CYP2C8 and UGT2B17) revealed that patients with high expression of ABCB4, CYP2C8, UGT2B4 or UGT2B17 had poorer survival than those with low expression