Table 3.
Cox regression analyses for the 1-year composite endpoint (all-cause death or HF related rehospitalization)
| 1-year composite endpoint | ||||||
|---|---|---|---|---|---|---|
| Univariate analysis | Multivariate analysis | |||||
| HR | 95%CI | p-value | HR | 95%CI | p-value | |
| Age | 1.04 | 1.02–1.06 | < 0.001 | 1.03 | 1.01–1.06 | 0.003 |
| Female sex | 1.28 | 0.96–1.70 | 0.09 | 1.64 | 1.20–2.23 | 0.002 |
| NYHA | 1.54 | 1.18–2.01 | 0.002 | – | – | – |
| Diabetes | 1.16 | 0.98–1.38 | 0.09 | |||
| Charlson comorbidity index | 1.15 | 1.08–1.22 | < 0.001 | 1.10 | 1.03–1.18 | 0.008 |
| Barthel index | 0.99 | 0.98–0.99 | < 0.001 | – | – | – |
| Urea | 1.01 | 1.01–1.01 | < 0.001 | 1.01 | 1.00–1.01 | < 0.001 |
| Creatinine | 1.00 | 1.00–1.01 | 0.3 | – | – | – |
| Hb | 0.90 | 0.82–0.98 | 0.01 | – | – | – |
| Na | 0.97 | 0.93–1.00 | 0.07 | |||
| NT-proBNPa | 1.43 | 1.25–1.65 | < 0.001 | 1.18 | 1.00–1.38 | 0.04 |
| ST2a | 1.63 | 1.44–1.85 | < 0.001 | 1.41 | 1.21–1.63 | < 0.001 |
| CA125a | 1.32 | 1.15–1.52 | < 0.001 | – | – | – |
| Hs-TnIa | 1.21 | 1.05–1.39 | 0.007 | – | – | – |
aLog-transformed and per 1 SD
CA125 cancer antigen 125, NT-proBNP N-terminal pro-brain natriuretic peptide, hs-TnI high-sensitivity troponin I, ST2 Interleukin-1 receptor-like 1