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. 2017 Dec 16;54(2):88–103. doi: 10.1016/j.jdsr.2017.11.001

Figure 6.

Figure 6

Proliferation of OSCC cell lines in monolayer culture. (Left side) EGFR signaling has an important role for the proliferation of HSC3 and HSC4. Addition of EGF induces the promotion of cell proliferation. Moreover, addition of EGFR inhibitor, such as cetuximab, AG1478, and lapatinib, inhibit the proliferation of these cell lines. (Right side) SAS also express EGFR on the plasma membrane. The cell proliferation is not inhibited by the EGFR inhibitors (cetuximab and AG1478). On the other hand, the addition of lapatinib, a dual inhibitor of EGFR and ErbB2 tyrosine kinase activity, inhibit the cell proliferation. Moreover, the addition of ErbB inhibitor II significantly inhibit the cell proliferation. These results suggest that proliferation of SAS needs the signaling of ErbB other than EGFR. In addition, the ErbB signaling phosphorylates and activates MAPK, which in turn phosphorylates and activates ERK. This signaling cascade promotes the SAS cell proliferation, consequently.