Skip to main content
. 2017 Dec 16;54(2):88–103. doi: 10.1016/j.jdsr.2017.11.001

Figure 7.

Figure 7

Proliferation of SAS in floating culture. SAS can proliferate in the anchorage-independent growth condition and form sphere. In this condition, activated receptors, including EGFR, assemble at lipid raft, which is a kind of platform of the plasma membrane. Not only lapatinib but also cetuximab and AG1478, inhibit the proliferation of SAS sphere. Moreover, LY294002, which is a PI3K inhibitor, and MK2206, which is an AKT inhibitor, suppress the amount of cyclin D2. Cyclin D2 is one of a regulator of cell cycle and contributes to the proliferation of SAS sphere.