Table 2.
Adjusted analysis of factors associated with liver-related mortality among people with an HBV and HCV notification, NSW 1993-2012, n = 150,403
| Characteristics, n % | HBV | HCV | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Deceaseda | aHRb | 95% CI | P | Deceaseda | aHRb | 95% CI | P | |||
| n = 582 | % | n = 2215 | % | |||||||
| Birth cohort | ||||||||||
| ≥ 1965 | 66 | < 1 | 1.00 | – | – | 247 | 1 | 1.00 | – | – |
| 1945-1964 | 304 | 1 | 6.19 | 4.72, 8.11 | < 0.001 | 1542 | 4 | 7.33 | 6.39, 8.40 | < 0.001 |
| ≤ 1944 | 212 | 5 | 28.07 | 21.02, 37.47 | < 0.001 | 426 | 9 | 31.88 | 26.83, 37.87 | < 0.001 |
| Gender | ||||||||||
| Female | 102 | < 1 | 1.00 | – | – | 559 | 2 | 1.00 | – | – |
| Male | 477 | 2 | 2.65 | 2.13, 3.30 | < 0.001 | 1654 | 3 | 1.47 | 1.33, 1.62 | < 0.001 |
| Missing | 3 | 1 | 1.44 | 0.45, 4.54 | 0.539 | 2 | 1 | 0.41 | 0.10, 1.64 | 0.208 |
| Country of birthc | ||||||||||
| Australia | 109 | 2 | 1.00 | – | – | 1024 | 3 | 1.00 | – | – |
| Asia-Pacific | 148 | 1 | 0.89 | 0.67, 1.19 | 0.425 | 130 | 3 | 1.07 | 0.88, 1.29 | 0.493 |
| Other | 76 | 2 | 0.91 | 0.67, 1.25 | 0.580 | 311 | 5 | 1.43 | 1.25, 1.63 | < 0.001 |
| Missing | 249 | 1 | 0.86 | 0.66, 1.12 | 0.268 | 750 | 2 | 0.88 | 0.79, 0.97 | 0.015 |
| Year of notification | ||||||||||
| ≤ 2000 | 316 | 1 | 1.00 | – | – | 1347 | 3 | 1.00 | – | – |
| 2001-2006 | 206 | 1 | 1.26 | 1.01, 1.58 | 0.041 | 627 | 2 | 1.48 | 1.32, 1.67 | < 0.001 |
| 2007-2012 | 60 | < 1 | 1.44 | 1.01, 2.06 | 0.045 | 241 | 1 | 2.98 | 2.47, 3.60 | < 0.001 |
| HBV/HCV co-infection | ||||||||||
| No | 461 | 1 | 1.00 | – | – | 2094 | 2 | 1.00 | – | – |
| Yes | 121 | 3 | 2.63 | 2.03, 3.41 | < 0.001 | 121 | 3 | 1.53 | 1.28, 1.85 | < 0.001 |
| HIV co-infection | ||||||||||
| No | 572 | 1 | 1.00 | – | – | 2186 | 2 | 1.00 | – | – |
| Yes | 10 | 3 | 3.46 | 1.83, 6.55 | < 0.001 | 29 | 3 | 1.78 | 1.23, 2.57 | 0.002 |
| Area of residence at the time of notification | ||||||||||
| Rural | 92 | 2 | 1.00 | – | – | – | – | – | – | – |
| Outer metropolitan | 262 | 1 | 1.02 | 0.78, 1.32 | 0.899 | – | – | – | – | – |
| Metropolitan | 227 | 1 | 0.84 | 0.65, 1.10 | 0.207 | – | – | – | – | – |
| Missing | 1 | < 1 | 0.21 | 0.03, 1.53 | 0.124 | – | – | – | – | – |
| History of alcohol-use disorder | ||||||||||
| No | 448 | 1 | 1.00 | – | – | 1050 | 1 | 1.00 | – | – |
| Yes | 134 | 7 | 6.98 | 5.54, 8.78 | < 0.001 | 1165 | 7 | 8.30 | 7.56, 9.10 | < 0.001 |
| History of OSTd | ||||||||||
| No | 538 | 1 | 1.00 | – | – | 1675 | 3 | 1.00 | – | – |
| Yes | 44 | 3 | 0.84 | 0.57, 1.25 | 0.391 | 540 | 2 | 0.92 | 0.82, 1.03 | 0.150 |
aRecords included 2002-2013, badjusted hazard ratio, cmajority of countries included in the other category were European (HBV n = 50, HCV n = 229). Non-European countries were included in the other category given the small numbers (HBV n = 26, HCV n = 72), dincluded as a time-dependent variable