Fig. 5.

RINCK promotes anti-DNA virus innate immune responses. a, b WT or RINCK-deficient U937 cells were infected with HSV-1 (MOI = 1) for indicated time followed by measuring IFN-β mRNA and HSV-1 RNA with qPCR. c WT or RINCK-deficient U937 cells were infected with HSV-1 (MOI = 1) for 24 h. The replication of HSV-1 was measured by plaque assay in HeLa cells. d The viral titer (plaque-forming units, PFU) in c was calculated. Data are presented as the mean ± SD. *P < 0.05, **P < 0.01. Data represent three independent experiments