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. 2018 May 9;37:101. doi: 10.1186/s13046-018-0745-z

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — The overexpression of tRNAs regulated the progression of cancer acting on different ways: Ras, c-myc and TERT promoted the transcription of tRNA genes by binding to pol III. a The overexpression of tRNA activated the RSK1/MSK2 signaling pathway, thus influencing cell proliferation and cell apoptosis. b Overexpressed tRNA promoted the ability of invasion and metastasis by enhancing stability and translation of transcripts enriched for their cognate codons. c The overexpression of tRNA regulated the progression of cancer by increasing the secretion of integrin and type II collagen