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. 2018 May 9;37:101. doi: 10.1186/s13046-018-0745-z

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — tRNA derivatives exerted their effects through different pathways. a tRNA derivatives promoted cell proliferation and the progression of G0/G1 cell cycle by regulating the expression of AURKA. b Both tRNA derivatives and endogenous oncogene transcripts competed with YBX1, suppressing the progression of cancer and preventing the translation of eIF4G/A. c tRNA derivatives promoted the translation of ribosomal protein mRNAs, subsequently enhancing cell proliferation and viability